Correlation of inflammatory biomarkers with disease severity in hospitalised patients of COVID-19 at presentation

  • Hijab Batool Chughtai Lab Lahore
  • M Dilawar Khan
  • Omar Rasheed Chughtai
  • Akhtar Sohail Chughtai
  • Shakeel Ashraf
  • Sana Amir
Keywords: COVID-19, Inflammation, IL-6, D-dimers, Ferritin, CRP, PCT


Background: The course of COVID-19 ranges from asymptomatic infection to life threatening critical illness. Inflammatory biomarkers have vital role in predicting outcome, disease severity and disease prognosis in COVID-19 cases. This study aims to observe the correlation of these biomarkers with disease severity in COVID-19.
Patients and methods: This cross-sectional study was conducted in Chughtai Institute of Pathology from February 2021 to May 2021. Blood was collected from 1300 hospitalized adult PCR confirmed COVID-19 patients categorized in mild to critical disease classes. Asymptomatic cases, patients having coagulopathies and those who received plasma infusion were excluded from the study. Blood was analyzed for serum Interleukin-6 (IL-6), Ferritin, C-reactive protein (CRP), procalcitonin and D Dimers. Data was analyzed using SPSS 23.0.
Results: From the study patients, 65.3% (n=849) were male and 34.7% (n=451) were female. Majority of the cases (43.5%, N=565) belonged to moderate group whereas only 0.6% (N=8) were in critical group. Study population had a mean age of 56 (+13.98) years. Serum IL-6 was taken as marker of disease severity, showed significant positive correlation with CRP (r =0.52), ferritin (r =0.33), D-dimers (r =0.32) but no correlation with procalcitonin (r =0.17) using spearmen correlation coefficient. All patients with critical disease had IL-6 levels above 1000pg/ml.
Conclusion: The inclusion of inflammatory biomarkers in routine panel of COVID-19 patients can allow risk stratification of COVID-19 patients in different disease severity groups as cases with critical disease had higher levels.

How to Cite
Batool H, Khan M, Chughtai O, Chughtai A, Ashraf S, Amir S. Correlation of inflammatory biomarkers with disease severity in hospitalised patients of COVID-19 at presentation. J Fatima Jinnah Med Univ [Internet]. 7Apr.2022 [cited 27Sep.2023];15(4):171-6. Available from: