Frequency of Drug Resistance Among Retreatment Tuberculosis Patients in Gulab Devi Chest Hospital
Keywords:
Multiple drug resistance, Category-II treatment, Failure cases, Retreatment regimen.Abstract
Objective: Emerging drug resistance is a global challenge. Efforts are underway to detect and treat this menace. We carried out this study to ascertain the frequency of MDR among Category-II pulmonary TB patients.
Methodology: In this cross-sectional descriptive study all MTB detected cases admitted in hospital OR being referred in OPD were included in the study. CAT-II cases subjected to GeneXpert analysis to detect MDR in terms of Rifampicin resistance. Including basic demographic details all the data were recorded in a short structured questionnaire.
Results: A total of 1085 MTB detected patients were included in this study. There was an overall male predominance (53%). Majority of our patients were in the range of 15-45 years of age. Out of 1085 patients Category-II treated patients were accounting 38% (411) of the total MTB cases. Rifampicin resistance was detected in 211 (54%) cases of the total Category-II treated patients.
Conclusion: Over all frequency of MDR in Category-II treated patients was 54%. Primary drug resistance was a strong risk factor for failure and relapse and for acquiring further resistance. As 59% of failure cases had RIF resistance, the standard re-treatment regimen appears inadequate for failure cases.
Downloads
Published
How to Cite
Issue
Section
License
The Journal of Fatima Jinnah Medical University follows the Attribution Creative Commons-Non commercial (CC BY-NC) license which allows the users to copy and redistribute the material in any medium or format, remix, transform and build upon the material. The users must give credit to the source and indicate, provide a link to the license, and indicate if changes were made. However, the CC By-NC license restricts the use of material for commercial purposes. For further details about the license please check the Creative Commons website. The editorial board of JFJMU strives hard for the authenticity and accuracy of the material published in the journal. However, findings and statements are views of the authors and do not necessarily represent views of the Editorial Board.
